Orthopaedics Research Group

The Orthopaedics Research Group (ORG) focuses on understanding specific orthopaedic pathologies, to better facilitate clinical transition of lab results to medical therapies. One core ongoing project investigates heterotopic ossification (HO) — a disease prevalent in soldiers who have sustained traumatic extremity injuries — identifying promising biomolecular targets for future treatments, as well as possible markers for gauging genetic susceptibility in patients who experience physical trauma. Another aspect of ORG research centers on a novel population of multipotent mesenchymal progenitor cells (MPCs) that can be extracted in high concentrations from surgical waste tissue following musculoskeletal trauma. These MPCs are capable of coordinating regenerative mechanisms, as well as differentiating into cell types native to the musculoskeletal system, making them highly attractive for clinical use and tissue replacement strategies. Other ORG active research areas include interrogation of genetic events and epigenetic profiles associated with the healing response, bioengineering scaffolds to influence musculoskeletal regeneration, and in situ surgical capture and application of MPCs to assist wound healing.

Selected Publications

Jackson WM, Aragon AB, Onodera J, Koehler SM, Ji Y, Bulken-Hoover JD, Vogler JA, Tuan RS, Nesti LJ. Cytokine expression in muscle following traumatic injury. J Orthop Res. 2011 Mar 30. PubMed Icon

Jackson WM, Lozito T, Djouad F, Kuhn NZ, Nesti LJ, Tuan RS. Differentiation and regeneration potential of mesenchymal progenitor cells derived from traumatized muscle tissue. J Cell Mol Med. 2010 Dec 3. PubMed Icon

Jackson WM, Nesti LJ, Tuan RS. Potential therapeutic applications of muscle-derived mesenchymal stem and progenitor cells. Expert Opin Biol Ther. 2010 Apr;10(4):505-17. PubMed Icon

Baechler MF, Groth AT, Nesti LJ, Martin BD. Soft tissue management of war wounds to the foot and ankle. Foot Ankle Clin. 2010 Mar;15(1):113-38. PubMed Icon

Jackson WM, Aragon AB, Bulken-Hoover JD, Nesti LJ, Tuan RS. Putative heterotopic ossification progenitor cells derived from traumatized muscle. J Orthop Res. 2009 Dec;27(12):1645-51. PubMed Icon

Jackson WM, Aragon AB, Djouad F, Song Y, Koehler SM, Nesti LJ, Tuan RS. Mesenchymal progenitor cells derived from traumatized human muscle. J Tissue Eng Regen Med. 2009 Feb;3(2):129-38. PubMed Icon

Shanti RM, Janjanin S, Li WJ, Nesti LJ, Mueller MB, Tzeng MB, Tuan RS. In vitro adipose tissue engineering using an electrospun nanofibrous scaffold.Ann Plast Surg. 2008 Nov;61(5):566-71. PubMed Icon

Nesti LJ, Jackson WM, Shanti RM, Koehler SM, Aragon AB, Bailey JR, Sracic MK, Freedman BA, Giuliani JR, Tuan RS. Differentiation potential of multipotent progenitor cells derived from war-traumatized muscle tissue. J Bone Joint Surg Am. 2008 Nov;90(11):2390-8. PubMed Icon

Nesti LJ, Li WJ, Shanti RM, Jiang YJ, Jackson W, Freedman BA, Kuklo TR, Giuliani JR, Tuan RS. Intervertebral disc tissue engineering using a novel hyaluronic acid-nanofibrous scaffold (HANFS) amalgam. Tissue Eng Part A. 2008 Sep;14(9):1527-37. PubMed Icon

See extended list of publications

Reviewed September 24, 2012