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Muscle Disease Unit
Dr. Mammen's research focuses on understanding the fundamental mechanisms of disease in different types of myositis, including dermatomyositis, polymyositis, statin-triggered necrotizing myopathy, and inclusion body myositis. The ultimate goal is to establish more effective treatments for patients with all forms of myositis.
Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA. Increased frequency of DRB1*11:01 in anti-hydroxymethylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Arthritis Care Res (Hoboken). 2012 Aug;64(8):1233-7.
Williams KM, Ostrow LW, Loeb DM, Chung T, Cohn RD, Corse AM, Mammen AL, Chen AR. Immunohistochemistry of affected tissue may guide cGVHD treatment decisions. Bone Marrow Transplant. 2012 May;47(5):731-3.
Mammen AL, Pak K, Williams EK, Brisson D, Coresh J, Selvin E, Gaudet D. Rarity of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in statin users, including those with self-limited musculoskeletal side effects. Arthritis Care Res (Hoboken). 2012 Feb;64(2):269-72.
Mammen AL, Mahoney JA, St Germain A, Badders N, Taylor JP, Rosen A, Spinette S. A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells. PLoS One. 2011;6(12):e28861.
Moghekar A, Rao S, Li M, Ruben D, Mammen A, Tang X, O'Brien RJ. Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro. J Biol Chem. 2011 May 6;286(18):15989-97.
Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Doering KR, Casciola-Rosen LA. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011 Mar;63(3):713-21.
Valiyil R, Casciola-Rosen L, Hong G, Mammen A, Christopher-Stine L. Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series. Arthritis Care Res (Hoboken). 2010 Sep;62(9):1328-34.
Christopher-Stine L, Casciola-Rosen LA, Hong G, Chung T, Corse AM, Mammen AL. A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum. 2010 Sep;62(9):2757-66.See extended list of publications
Updated July 10, 2014