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Muscle Disease Unit
Dr. Mammen's research focuses on human muscle disease as well the basic biology of skeletal muscle regeneration. In particular, his lab aims to understand the fundamental mechanisms of disease in different types of autoimmune muscle disease, including dermatomyositis, polymyositis, and statin-triggered necrotizing myopathy. Furthermore, since his lab has shown that targets of the immune system in myositis play a role in muscle differentiation, ongoing work seeks to further characterize these biological pathways with a view to identifying novel therapeutic targets to promote muscle regeneration.
Mammen AL, Gaudet D, Brisson D, Christopher-Stine L, Lloyd TE, Leffell MS, Zachary AA. Increased frequency of DRB1*11:01 in anti-hydroxymethylglutaryl-coenzyme A reductase-associated autoimmune myopathy. Arthritis Care Res (Hoboken). 2012 Aug;64(8):1233-7.
Williams KM, Ostrow LW, Loeb DM, Chung T, Cohn RD, Corse AM, Mammen AL, Chen AR. Immunohistochemistry of affected tissue may guide cGVHD treatment decisions. Bone Marrow Transplant. 2012 May;47(5):731-3.
Mammen AL, Pak K, Williams EK, Brisson D, Coresh J, Selvin E, Gaudet D. Rarity of anti-3-hydroxy-3-methylglutaryl-coenzyme A reductase antibodies in statin users, including those with self-limited musculoskeletal side effects. Arthritis Care Res (Hoboken). 2012 Feb;64(2):269-72.
Mammen AL, Mahoney JA, St Germain A, Badders N, Taylor JP, Rosen A, Spinette S. A novel conserved isoform of the ubiquitin ligase UFD2a/UBE4B is expressed exclusively in mature striated muscle cells. PLoS One. 2011;6(12):e28861.
Moghekar A, Rao S, Li M, Ruben D, Mammen A, Tang X, O'Brien RJ. Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro. J Biol Chem. 2011 May 6;286(18):15989-97.
Mammen AL, Chung T, Christopher-Stine L, Rosen P, Rosen A, Doering KR, Casciola-Rosen LA. Autoantibodies against 3-hydroxy-3-methylglutaryl-coenzyme A reductase in patients with statin-associated autoimmune myopathy. Arthritis Rheum. 2011 Mar;63(3):713-21.
Valiyil R, Casciola-Rosen L, Hong G, Mammen A, Christopher-Stine L. Rituximab therapy for myopathy associated with anti-signal recognition particle antibodies: a case series. Arthritis Care Res (Hoboken). 2010 Sep;62(9):1328-34.
Christopher-Stine L, Casciola-Rosen LA, Hong G, Chung T, Corse AM, Mammen AL. A novel autoantibody recognizing 200-kd and 100-kd proteins is associated with an immune-mediated necrotizing myopathy. Arthritis Rheum. 2010 Sep;62(9):2757-66.See extended list of publications
Updated September 11, 2014