NIAMS IRP Retreat 2013

Agenda

Lister Hill Auditorium
NIH campus, Bethesda
June 5-6, 2013

Day 1: Wednesday, June 5
Day 2: Thursday, June 6

Day 1:       Wednesday, June 5

8:00 a.m. - 8:30 a.m. Registration
8:30 a.m. – 8:45 a.m.

Welcome
Chair, Rafael Casellas, Ph.D., Senior Investigator, NIAMS
Co-Chair, Bob Colbert, M.D., Ph.D., Deputy Clinical Director, NIAMS
Robert Carter, M.D., Deputy Director, NIAMS
John O’Shea, M.D., NIAMS Scientific Director

8:45 a.m. – 9:45 a.m. Keynote speaker: Barry Sleckman, M.D., Ph.D.
“At the Intersection of DNA Damage and Immune Responses”
Conan Professor of Pathology and Immunology
Washington University
9:45 a.m. – 10:45 a.m. Keynote speaker: Jean Laurent Casanova, M.D., Ph.D.
“Toward a Genetic Theory of Childhood Infectious Diseases”
Professor, Head of Laboratory
St. Giles Laboratory of Human Genetics of Infectious Diseases
The Rockefeller University
10:45 a.m. - 12:00 p.m. Poster Session I
12:00 p.m. – 1:15 p.m. Lunch Break
1:15 p.m. – 2:15 p.m.

General Session I
Moderator: Vittorio Sartorelli, M.D.

Presenters:
Elisabetta Palazzo, Ph.D.
“Skin Differentiation and Tumor Development”
Laboratory of Skin Biology


Kiyoshi Hirahara, M.D., Ph.D.
“Bach2 Represses Effector Programs to Stabilize Treg-Mediated Immune Homeostasis”
Molecular and Inflammation Branch


Juan Fontana, Ph.D.
“Encapsulins (Used by Bacteria to Encapsulate Enzymes to Compartmentalize Their Metabolism)”
Laboratory of Structural Biology Research

2:15 p.m. – 3:15 p.m. Keynote speaker: Yijun Ruan, Ph.D.
“Topological Basis of Higher-Order Chromatin Folding And Gene Transcription Regulation in Human Cells”
Professor and Director for Genomic Sciences
The Jackson Laboratory for Genomic Medicine
3:14 p.m. – 4:00 p.m. Poster Session I (continued)
3:45 p.m. – 4:45 p.m.

General Session II
Moderator: Richard Siegel, M.D., Ph.D.

Presenters:
Ewy Mathe, Ph.D.
“DNA Methylation Demarcates Cell-Type Specific Enhancers”
Genomics and Immunity Section


Qing Zhou, Ph.D.
“Mutations in CERC1 Cause Early Strokes with Fever”
Medical Genetics Branch, NHGRI


Giuseppina Caretti, Ph.D.
“The Methyltransferase SMYD3 Regulates Skeletal Muscle Atrophy”
Laboratory of Muscle Stem Cells and Gene Regulation

Day 2:       Thursday, June 6

8:30 a.m. – 9:30 a.m. Welcome
Co-Chair, Bob Colbert, M.D., Ph.D.
Keynote speaker: Michael Weinblatt, M.D.
“RA Therapy – Past, Present, and Future”
John R. and Eileen K. Riedman Professor of Medicine
Brigham and Women’s Hospital
Harvard Medical School
9:30 a.m. – 10:30 a.m. Keynote speaker: Patrick Wilson, Ph.D.
“B Cell Mediated Immunity to Influenza”
Associate Professor, Department of Medicine/Rheumatology
Knapp Center for Lupus and Immunology Research
The University of Chicago
10:30 a.m. – 12:00 p.m. Poster Session II
12:00 p.m. – 1:00 p.m. Lunch
1:00 p.m. – 2:00 p.m. Special session: Barrett Whitener, M.A.
“Scientifically Speaking: How to Prepare an Effective Talk”
IQ Solutions, Rockville, MD
2:00 p.m. – 2:40 p.m.

General Session III
Moderator: Bob Colbert, M.D., Ph.D.

Presenters:
Martin Pelletier, Ph.D.
“Dissecting the Role of Energy Metabolism in the Familial Autoinflammatory Disease TRAPS (TNF Receptor-Associated Periodic Syndrome)”
Autoimmunity Branch


Chao Jiang, Ph.D.
“Type I Interferon Signature is Tightly Associated with High Levels of Auto- Reactive IgE Antibodies in Systemic Lupus Erythematosus”
Laboratory of Molecular Immunogenetics

2:40 p.m. – 3:40 p.m.

General Session IV - Research Proposals by Second Year Clinical Fellows
Moderator: Richard Siegel, M.D., Ph.D.

Presenters:
Sarthak Gupta, M.D.
“Anticytokine Autoantibodies in Rheumatic Diseases”
Rheumatology Fellowship and Training Branch


Cornelia Cudrici, M.D.
“AMP-Activated Protein Kinase: A Target for DMARDs (Disease Modifying Anti-Rheumatic Drugs”
Rheumatology Fellowship and Training Branch


Runsheng (Bridget) Wang, M.D.
“Immunomodulatory Function of Mesenchymal Stem Cells”
Rheumatology Fellowship and Training Branch


Hanna Kim, M.D.
“Interferonopathies – Interferon Signatures, Cytokines, and Phenotypes”
Translational Autoinflammatory Diseases Section

3:40 p.m. – 3:55 p.m. Break
3:55 p.m. – 4:55 p.m.

General Session V - Abstract Presentations – NIAMS Scholars
Moderator: Bob Colbert, M.D., Ph.D.

Presenters:
Peter Grayson, M.D.
“Nasal Gene Expression Profiling in ANCA Vasculitis and Candidate Genes for Disease Causality ”
Program in Translational Research


Michael Ombrello, M.D.
“Genome Wide Association Study of Still’s Disease Identifies Three Susceptibility Loci”
Translational Genetics and Genomics Unit


Eric Hanson, M.D.
“Mechanisms of Inflammatory Disease Revealed by Human Mutations in NEMO, the NF-kB Essential Modulator”
Autoimmunity Branch

4:55 p.m. – 5:10 p.m.

Concluding remarks
John O’Shea, M.D., NIAMS Scientific Director