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  • In exchange for a two or three-year (for Intramural General Research) commitment to your research career, NIH will repay up to $35,000 per year of your qualified educational debt. See NIH Loan Repayment Programs

Research in NIAMS Labs

Updated March 23, 2015

Photo of Dr. John O'Shea, NIAMS Scientific Director

Welcome to NIAMS Labs from Dr. John O'Shea, NIAMS Scientific Director

As you will see, our program comprises scientists, physicians, nurses, trainees and administrators who work together to solve basic scientific problems and devise new treatments for arthritis, musculoskeletal and skin diseases.

Photo of Dr. Siegel and a colleague in the lab.

NIAMSí Intramural Research Programs Foster Spirit of Discovery

The Rheumatologist profiles investigators from NIAMS' IRP working in immunology and rheumatology, describing NIAMS' "long tradition of scientific innovation."

Electron micrograph of a human T cell.

NIH Researchers Reveal Link Between Powerful Gene Regulatory Elements and Autoimmune Diseases

NIAMS research fellow Golnaz Vahedi and other NIH intramural and extramural investigators have discovered the genomic switches of a blood cell key to regulating the human immune system.

Illustration from Dr. Sartorelli's SIRT1 poster

SIRT1 Links Metabolism to Gene Expression in Skeletal Muscle Stem Cells

Sirtuin 1 (SIRT1) is an enzyme that regulates gene expression by removing acetyl groups from DNA-associated proteins. New research from the Sartorelli lab reveals that metabolic changes affect SIRT1 activity, thus leading to altered gene expression in the stem cells of skeletal muscle.

Illustration of a dartboard showing how AID targets super-enhancers.

Casellas lab identifies mechanisms that facilitate the formation of B cell tumors

This work identifies super-enhancers and key elements that recruit activation-induced cytidine deaminase (AID), thus leading to DNA strand breaks in B cell proto-oncogenes. These AID-induced mutations contribute to formation of B cell lymphomas.