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Research in NIAMS Labs

Updated February 1, 2016

Illustration showing MacroH2A1.2 as a lighthouse.

NIAMS Laboratory Has New Paper on Histone Variants

MacroH2A1.2 is a histone variant required for activation of regulatory networks that control gene expression. New research from the Sartorelli lab reveals that macroH2A1.2 marks the regulatory regions for gene activation in muscle cells and serves as a guide for chromatin recruitment of Pbx1 and subsequent binding of MyoD.

Photo of Dr.Kaplan, Dr. Luz Blanco and Monica Purmalek.

Research Identifies Factors Contributing to Autoimmunity

A new paper from Dr. Mariana Kaplan, chief of the Systemic Autoimmunity Branch, identifies a novel role for reactive oxygen species generated by the mitochondria, as well as for oxidation of mitochondrial DNA, in the generation of abnormal neutrophil responses and promotion of autoimmunity in systemic lupus erythematosus. This may lead to the identification of new targets for future treatments for this disease.

Photo of rods forming tooth enamel.

Dr. Olivier Duverger Selected as 2015 FASEB BioArt Winner

Dr. Olivier Duverger, staff scientist in the Developmental Skin Biology Section, is among the winners of the 2015 FASEB BioArt Competition. The FASEB BioArt Competition showcases the artistic side of biomedical research images. Dr. Duverger’s winning image (left) is a scanning electron micrograph displaying the lattice structure formed by enamel rods, the building blocks of tooth enamel.

Photo of Dr. Kaplan in the lab.

Dr. Mariana Kaplan receives Evelyn V. Hess Award

Congratulations to Dr. Mariana Kaplan, Chief of the Systemic Autoimmunity Branch, who was selected as the recipient of the 2015 Evelyn V. Hess Award by the Lupus Foundation of America. This award is presented to individuals who have made significant contributions to lupus research, diagnosis, and treatment. NIAMS is proud of Dr. Kaplan for this outstanding achievement.

Photo of Dr. Kanno.

NIAMS Scientist Selected as Visiting Professor

Dr. Yuka Kanno, staff scientist in the Molecular Immunology and Inflammation Branch, was invited to Paris to give a lecture to students and faculty of the Vaccine Research Institute at University of Paris-Est Créteil. Dr. Kanno visited the university on October 19th to give a lecture on epigenetics/transcriptional memory and vaccination.